Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
USERS' SCORE
Good
Based on 39 Reviews
8.8
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Vitamin K2(as Menaquinone-7) (MK-7 ) (MenaQ7®)
100 mcg
**
Top Medical Research Studies
8
We evaluated the effectiveness of vitamin K antagonists (VKAs) in treating left ventricular thrombosis (LVT). Over a year, a cohort of 90 patients was observed for LVT resolution and complications.
By the end of the study, approximately 70% of participants saw their blood clots resolve, with lower success rates linked to factors like reduced heart function. While VKAs showed promise, the treatment's safety profile was also notable, with few severe complications reported.
By the end of the study, approximately 70% of participants saw their blood clots resolve, with lower success rates linked to factors like reduced heart function. While VKAs showed promise, the treatment's safety profile was also notable, with few severe complications reported.
Read More
8
Thrombosis incidence varies by anticoagulant
We investigated the incidence of bioprosthetic mitral valve thrombosis (bMVT) after transcatheter and surgical mitral valve replacements. Analyzing data from 47 studies involving over 6,000 patients revealed that bMVT occurs more frequently in patients undergoing transcatheter procedures, though not significantly.
Interestingly, those treated with vitamin K antagonists experienced a notably lower incidence of bMVT compared to those on direct oral anticoagulants. This suggests that the choice of anticoagulant could influence thrombotic risks after these heart surgeries.
Interestingly, those treated with vitamin K antagonists experienced a notably lower incidence of bMVT compared to those on direct oral anticoagulants. This suggests that the choice of anticoagulant could influence thrombotic risks after these heart surgeries.
Read More
7
VKA treatment outcomes in atrial fibrillation
Our study involved a group of 1,350 patients with valvular and nonvalvular atrial fibrillation, all receiving vitamin K antagonists (VKAs). Over about 17 months, we noted an annual incidence of 4.4% for serious events like cardiovascular death and thromboembolic occurrences.
Key predictors included a history of thromboembolism and bleeding, low time in therapeutic range, and reduced kidney function. Notably, while VKAs are crucial, they come with risks that we need to monitor closely to improve patient outcomes.
Key predictors included a history of thromboembolism and bleeding, low time in therapeutic range, and reduced kidney function. Notably, while VKAs are crucial, they come with risks that we need to monitor closely to improve patient outcomes.
Read More
Most Useful Reviews
10
Essential for health
236 people found this helpful
Vitamin D3 aids in calcium absorption, but it’s vitamin K2 that ensures the calcium is directed where it's needed. Without K2, calcium settles in blood vessels, which can be life-threatening. Taking both D3 and K2 together is essential for health.
Read More
10
Critical pairing
209 people found this helpful
I was prescribed a high dose of vitamin D3 but was informed that without vitamin K2, it could be hazardous for my blood vessels. K2 ensures that calcium goes where it’s needed rather than accumulating in the bloodstream. It's crucial to take them together.
Read More
9
Calcium management
18 people found this helpful
Everyone should take vitamin K2 with vitamin D3 to strengthen bones. K2 directs calcium away from arteries and kidneys, preventing calcifications and promoting bone health. I recommend a daily dose of 5,000 units for optimal results.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 16 Researches
7.1
- All Researches
8
We examined a narrative review that highlights the effectiveness and safety of the four-factor prothrombin complex concentrate (4F-PCC), particularly Octaplex/Balfaxar. This treatment is designed to enhance clot formation and is available for reversing the effects of vitamin K antagonists like warfarin.
Over 20 years of clinical use revealed that 4F-PCC significantly lowers the international normalized ratio (INR) in patients, helping them achieve better clotting. Interestingly, only a couple of treatment-related thrombotic events were noted, indicating a balanced approach toward clotting without excessive risk.
Over 20 years of clinical use revealed that 4F-PCC significantly lowers the international normalized ratio (INR) in patients, helping them achieve better clotting. Interestingly, only a couple of treatment-related thrombotic events were noted, indicating a balanced approach toward clotting without excessive risk.
Read More
8
We evaluated the effectiveness of vitamin K antagonists (VKAs) in treating left ventricular thrombosis (LVT). Over a year, a cohort of 90 patients was observed for LVT resolution and complications.
By the end of the study, approximately 70% of participants saw their blood clots resolve, with lower success rates linked to factors like reduced heart function. While VKAs showed promise, the treatment's safety profile was also notable, with few severe complications reported.
By the end of the study, approximately 70% of participants saw their blood clots resolve, with lower success rates linked to factors like reduced heart function. While VKAs showed promise, the treatment's safety profile was also notable, with few severe complications reported.
Read More
8
We aimed to find the best antithrombotic regimen for patients with atrial fibrillation (AF) who recently experienced acute coronary syndrome (ACS) or had a percutaneous coronary intervention (PCI).
In our analysis of a randomized clinical trial, we compared apixaban, a novel anticoagulant, to vitamin K antagonists and evaluated the overall safety and efficiency of these treatments.
Our results showed that apixaban effectively reduced major bleeding events without increasing ischemic risks compared to vitamin K. We recommend using apixaban with a low-potency P2Y inhibitor as the standard care approach.
In our analysis of a randomized clinical trial, we compared apixaban, a novel anticoagulant, to vitamin K antagonists and evaluated the overall safety and efficiency of these treatments.
Our results showed that apixaban effectively reduced major bleeding events without increasing ischemic risks compared to vitamin K. We recommend using apixaban with a low-potency P2Y inhibitor as the standard care approach.
Read More
8
Thrombosis incidence varies by anticoagulant
We investigated the incidence of bioprosthetic mitral valve thrombosis (bMVT) after transcatheter and surgical mitral valve replacements. Analyzing data from 47 studies involving over 6,000 patients revealed that bMVT occurs more frequently in patients undergoing transcatheter procedures, though not significantly.
Interestingly, those treated with vitamin K antagonists experienced a notably lower incidence of bMVT compared to those on direct oral anticoagulants. This suggests that the choice of anticoagulant could influence thrombotic risks after these heart surgeries.
Interestingly, those treated with vitamin K antagonists experienced a notably lower incidence of bMVT compared to those on direct oral anticoagulants. This suggests that the choice of anticoagulant could influence thrombotic risks after these heart surgeries.
Read More
8
NOACs outperform VKAs in treatment
We examined how novel oral anticoagulants (NOACs) compare to vitamin K antagonists (VKAs) in treating blood clots in patients with nonvalvular atrial fibrillation.
In our review of 12 studies with nearly 1,000 participants, we found that NOACs achieved better clot-clearing results than VKAs, with a rate of 78% compared to 64%. Importantly, there were no significant differences in safety between these treatments.
Thus, NOACs appear to be a more effective option without increasing adverse events, suggesting a promising alternative for managing blood clots in these patients.
In our review of 12 studies with nearly 1,000 participants, we found that NOACs achieved better clot-clearing results than VKAs, with a rate of 78% compared to 64%. Importantly, there were no significant differences in safety between these treatments.
Thus, NOACs appear to be a more effective option without increasing adverse events, suggesting a promising alternative for managing blood clots in these patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 39 Reviews
8.8
- All Reviews
- Positive Reviews
- Negative Reviews
10
Essential for health
236 people found this helpful
Vitamin D3 aids in calcium absorption, but it’s vitamin K2 that ensures the calcium is directed where it's needed. Without K2, calcium settles in blood vessels, which can be life-threatening. Taking both D3 and K2 together is essential for health.
Read More
10
Critical pairing
209 people found this helpful
I was prescribed a high dose of vitamin D3 but was informed that without vitamin K2, it could be hazardous for my blood vessels. K2 ensures that calcium goes where it’s needed rather than accumulating in the bloodstream. It's crucial to take them together.
Read More
9
Calcium management
18 people found this helpful
Everyone should take vitamin K2 with vitamin D3 to strengthen bones. K2 directs calcium away from arteries and kidneys, preventing calcifications and promoting bone health. I recommend a daily dose of 5,000 units for optimal results.
Read More
9
Reduces blood clot risks
16 people found this helpful
Vitamin K2 (MK-7) enhances arterial elasticity and may lower mortality rates. A daily dosage of 180 mcg can be beneficial for postmenopausal women and men over 55, especially those on statins. It supports calcium absorption and reduces the risk of heart disease and osteoporosis. I find this brand less appealing; I purchased it for comparison.
Read More
9
Nosebleed cessation
12 people found this helpful
Increasing my vitamin K intake has remarkably eliminated my nosebleeds, a persistent issue since childhood. I adjusted my vitamin D and K dosage, finding that the higher intake of K2 prevented bleeding and improved my overall blood health.
Read More
Frequently Asked Questions
7.5
Blood pressure reduction
14 people found this helpful
Initially, I took the vitamin for calcium absorption but noticed it significantly lowered my high blood pressure, which had been concerning. After two weeks, it stabilised, demonstrating the additional health benefits of K2 alongside calcium.
9
Nosebleed cessation
12 people found this helpful
Increasing my vitamin K intake has remarkably eliminated my nosebleeds, a persistent issue since childhood. I adjusted my vitamin D and K dosage, finding that the higher intake of K2 prevented bleeding and improved my overall blood health.
9
Improves blood clotting
1 people found this helpful
My son has a blood clotting deficiency, and this product has worked wonders! It has significantly reduced the severity of his nosebleeds and they occur less frequently. Cuts and scrapes now clot appropriately. His blood clot numbers are improving since using this supplement. I highly recommend it but advise consulting with a doctor beforehand, especially for those with haemophilia.
8
Increased vitamin D
8 people found this helpful
After initially struggling to raise my vitamin D levels, I found that taking vitamin D with MK-7 helped significantly. The genetic test confirmed no issues with osteoporosis, and within a month of taking MK-7, my vitamin D levels improved.
6
Bone health restoration
18 people found this helpful
While supplementing vitamin D3, I realised the need for vitamin K2 to transport calcium into the bones, preventing complications like hypercalcemia. Since starting this, my bone pain has eased, and my overall health has improved significantly. K2 has become essential for me.
9
Supports blood clotting
1 people found this helpful
I give my husband vitamin K-2 as a cofactor with high doses of vitamin D-3 to address his deficiency. MK-7 does not increase blood clotting, which is crucial for those with thrombosis or varicose veins. It’s essential to supplement with proof from test results.
6
Helps blood coagulation
3 people found this helpful
I take vitamin K-2 with my high-dose vitamin D-3 as insurance against blood clotting issues. I selected MK-7 as it appears to have better absorption and supports proper blood coagulation when needed.
9
Essential combination
2 people found this helpful
I was prescribed 5000 units of vitamin D3 due to deficiency, but discovered it’s risky to take without vitamin K2. D3 absorbs calcium into the blood, while K2 helps ensure it reaches the bones, preventing deposition in blood vessels, which could be dangerous. This duo is vital for my health.
9
Reduces blood clot risks
16 people found this helpful
Vitamin K2 (MK-7) enhances arterial elasticity and may lower mortality rates. A daily dosage of 180 mcg can be beneficial for postmenopausal women and men over 55, especially those on statins. It supports calcium absorption and reduces the risk of heart disease and osteoporosis. I find this brand less appealing; I purchased it for comparison.
9
Prevents blood clotting
1 people found this helpful
Vitamin K2 (MK-7) uniquely does not cause blood hypercoagulability, activating liver proteins for coagulation without increasing blood clotting. It should be taken regularly with vitamin D3 to help transfer calcium from vessels to bones. Together, MK-7 and D3 may help prevent vascular calcification and osteoporosis, while high doses of vitamin K2 can lower cholesterol levels and slow atherosclerosis progression. The 100 mcg dosage is optimal, and the small capsules are undamaged.
7.5
Calcium to bones
3 people found this helpful
K-2 with D-3 enhances calcium movement into bones. As we age, our bodies become less efficient at transferring calcium from the bloodstream into our bones. This product, taken with D-3, aids in achieving that. After months of using 100 mcg of K-2, I’m reducing my intake to 45 mcg daily.
6
Avoids blood thickening
4 people found this helpful
I consistently buy vitamin D from this brand as I take high doses. The MK-7 form of vitamin K is essential, as it does not cause blood thickening and helps deliver calcium where needed, preventing blood clot issues.
8
We evaluated the effectiveness of vitamin K antagonists (VKAs) in treating left ventricular thrombosis (LVT). Over a year, a cohort of 90 patients was observed for LVT resolution and complications.
By the end of the study, approximately 70% of participants saw their blood clots resolve, with lower success rates linked to factors like reduced heart function. While VKAs showed promise, the treatment's safety profile was also notable, with few severe complications reported.
By the end of the study, approximately 70% of participants saw their blood clots resolve, with lower success rates linked to factors like reduced heart function. While VKAs showed promise, the treatment's safety profile was also notable, with few severe complications reported.
8
We examined a narrative review that highlights the effectiveness and safety of the four-factor prothrombin complex concentrate (4F-PCC), particularly Octaplex/Balfaxar. This treatment is designed to enhance clot formation and is available for reversing the effects of vitamin K antagonists like warfarin.
Over 20 years of clinical use revealed that 4F-PCC significantly lowers the international normalized ratio (INR) in patients, helping them achieve better clotting. Interestingly, only a couple of treatment-related thrombotic events were noted, indicating a balanced approach toward clotting without excessive risk.
Over 20 years of clinical use revealed that 4F-PCC significantly lowers the international normalized ratio (INR) in patients, helping them achieve better clotting. Interestingly, only a couple of treatment-related thrombotic events were noted, indicating a balanced approach toward clotting without excessive risk.
5
DOACs and VKAs show similar effectiveness
We looked into the effectiveness and safety of direct oral anticoagulants (DOACs) compared to vitamin K antagonists (VKAs) for cerebral venous thrombosis treatment. Conducted in 65 hospitals across 23 countries, this study found that the occurrence of major bleeding or recurrent clots was similar between both treatment options.
With over 600 patients involved, we observed that only a small percentage experienced these adverse outcomes within six months. Thus, both DOACs and VKAs appear to be valid choices for treating this condition, offering new insights into patient care.
With over 600 patients involved, we observed that only a small percentage experienced these adverse outcomes within six months. Thus, both DOACs and VKAs appear to be valid choices for treating this condition, offering new insights into patient care.
8
NOACs outperform VKAs in treatment
We examined how novel oral anticoagulants (NOACs) compare to vitamin K antagonists (VKAs) in treating blood clots in patients with nonvalvular atrial fibrillation.
In our review of 12 studies with nearly 1,000 participants, we found that NOACs achieved better clot-clearing results than VKAs, with a rate of 78% compared to 64%. Importantly, there were no significant differences in safety between these treatments.
Thus, NOACs appear to be a more effective option without increasing adverse events, suggesting a promising alternative for managing blood clots in these patients.
In our review of 12 studies with nearly 1,000 participants, we found that NOACs achieved better clot-clearing results than VKAs, with a rate of 78% compared to 64%. Importantly, there were no significant differences in safety between these treatments.
Thus, NOACs appear to be a more effective option without increasing adverse events, suggesting a promising alternative for managing blood clots in these patients.
References
- Karkouti K, Gareis M, Li C, Brandstätter H, Pichotta A, et al. Twenty years of the four-factor prothrombin complex concentrate Octaplex/Balfaxar: A narrative review. Transfus Apher Sci. 2025;64:104115. doi:10.1016/j.transci.2025.104115
- Valeriani E, Astorri G, Pannunzio A, Pastori D, Palumbo IM, et al. Long-term left ventricular thrombosis resolution in patients receiving vitamin k antagonists: a multicenter observational study. Intern Emerg Med. 2025. doi:10.1007/s11739-025-03922-6
- Geertsema-Hoeve BC, Radin M, Sciascia S, Urbanus RT, Huisman A, et al. Problem Solved? An Individual Ratio between Point-of-Care and Venous International Normalized Ratio Values in Two Patients with Antiphospholipid Syndrome: Two Case Reports. TH Open. 2025;9:a25425358. doi:10.1055/a-2542-5358
- Last J, Birschmann I, Lindau S, Konstantinides S, Grottke O, et al. Anticoagulant Management After Emergency Surgery or Major Bleeding in Anticoagulated Patients-Results of the Prospective RADOA Registry. Pharmaceuticals (Basel). 2025;18. doi:10.3390/ph18020170
- van de Munckhof A, van Kammen MS, Tatlisumak T, Krzywicka K, Aaron S, et al. Direct oral anticoagulants versus vitamin K antagonists for cerebral venous thrombosis (DOAC-CVT): an international, prospective, observational cohort study. Lancet Neurol. 2025;24:199. doi:10.1016/S1474-4422(24)00519-2
- Liporace IL, Oliveira GBF, Alves LBO, Galassi NM, Jeronimo AD, et al. Incidence and Predictors of Clinical Outcomes in Patients with Valvular and Nonvalvular Atrial Fibrillation Using Vitamin K Antagonists. Arq Bras Cardiol. 2025;122:e20240147. doi:10.36660/abc.20240147
- Hall EH, Sølsnes MH, Sandberg S, Sølvik UØ. Patient self-management of warfarin therapy - a long-term follow up study. Thromb J. 2025;23:14. doi:10.1186/s12959-025-00694-z
- Liu Y, Lam SHM, Romiti GF, Huang B, Chen Y, et al. Renal function and adverse clinical events in anticoagulated patients with atrial fibrillation: insights from the GLORIA-AF Registry Phase III. J Thromb Thrombolysis. 2025;58:165. doi:10.1007/s11239-025-03067-5
- Tannu M, Lopes RD, Wojdyla DM, Goodman SG, Aronson R, et al. Antithrombotic Therapy to Minimize Total Events After ACS or PCI in Atrial Fibrillation: Insights From AUGUSTUS. J Am Coll Cardiol. 2025;85:1157. doi:10.1016/j.jacc.2024.10.125
- Zorman MJ, Vibhishanan J, Dangas K, Castle J, Li KHC, et al. Valve Thrombosis and Antithrombotic Therapy After Bioprosthetic Mitral Valve Replacement: A Systematic Review And Meta-Analysis. Eur Heart J Cardiovasc Pharmacother. 2025. doi:10.1093/ehjcvp/pvaf005
- Mo GL, Wen J, Ye YY, Lu YQ, Gan TM, et al. Efficacy and Safety of New Oral Anticoagulants versus Warfarin in the Resolution of Atrial Fibrillation with Left Atrial/Left Atrial Appendage Thrombus: A Systematic Review and Meta-Analysis. Rev Cardiovasc Med. 2025;26:26055. doi:10.31083/RCM26055
- Kempers EK, Visser C, Geijteman ECT, Goedegebuur J, Portielje JEA, et al. Discontinuation of Anticoagulants and Occurrence of Bleeding and Thromboembolic Events in Vitamin K Antagonist Users with a Life-limiting Disease. Thromb Haemost. 2025. doi:10.1055/a-2524-5334
- Himmelreich JCL, Virdone S, Camm AJ, Pieper K, Harskamp RE, et al. Emulation of ARISTOTLE and ROCKET AF trials in real-world atrial fibrillation patients results in similar efficacy and safety as original landmark trials: insights from the GARFIELD-AF registry. Open Heart. 2025;12. doi:10.1136/openhrt-2024-002966
- Mapelli M, Celeste F, Maiolo G, Mancini E, Agostoni P. Incidental Diagnosis of Massive Mobile Left Ventricle Thrombi Following COVID-19 in a Heart Failure Patient. JACC Case Rep. 2024;29:102870. doi:10.1016/j.jaccas.2024.102870
- Gustafsson F, Uriel N, Netuka I, Katz JN, Pagani FD, et al. Aspirin and Hemocompatibility After LVAD Implantation in Patients With Atherosclerotic Vascular Disease: A Secondary Analysis From the ARIES-HM3 Randomized Clinical Trial. JAMA Cardiol. 2025;10:235. doi:10.1001/jamacardio.2024.4849
- Premkumar M, Bhujade H, Sharma P, Nain J, Ahluwalia J, et al. Experience With Dabigatran on Rate of Portal Vein Thrombosis Recanalization, Disease Progression and Survival. Aliment Pharmacol Ther. 2025;61:971. doi:10.1111/apt.18474
